It's weird and great that they got Sean Murray in on this.
Cargo plane sequence - yes. The train sequence - yes. But for me, it's not any one moment. It's... the Uncharted gameplay language that they really nailed in 2 and refined in 3.
Or if it is one moment, it's the moment when I leapt from a platform while still firing an assault-rifle one-handed at an enemy behind me as I flew through the air.